Videos

May 12, 2024

Drug Repurposing in the Corona Project

“COVID was the greatest drug-repurposing effort ever globally…so there's just a ton of noise in an effort like that.” How to deal with such noise? “do your best to uncover objective reality with the proper scientific research tools that we have” — Grant Mitchell on the Corona Project… Full episode:…

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May 11, 2024

The Near-Future of Automated Hypotheses Testing with AI

“You [can] use AI not only to digest and understand medical literature, but use it to generate its own hypotheses…combine that with robotics and automated labs….and repeat until it actually advances science on its own.” — Grant Mitchell on the near-future of AI testing out its own hypotheses… Full episode:…

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May 9, 2024

Grant Mitchell — The Potential of AI Drug Repurposing | Episode 215

Grant Mitchell is a seasoned entrepreneur, operator, and investor in the areas of health, technology, and machine learning. He is currently the co-founder and CEO of Every Cure, where he uses AI to research rare diseases and conduct drug repurposing. Grant joins the show to discuss the use of AI…

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May 7, 2024

Everybody Suffers from Impostor Syndrome

“At some point in their lives [geniuses] thought they were gigantic imposters, and some of them still do, and they still do it anyway.” — Jimmy Soni on how even geniuses suffered from impostor syndrome… Full episode: https://www.youtube.com/watch?v=-ynxoEjMaSA

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May 6, 2024

How Incentives can Restrict Risky Ideas

“There are editors at a big publisher that have wanted to really take a chance on a project, but they just weren't able to because of economic incentives or internal dissension…” — Jimmy Soni on taking chances on risky media ideas… Full episode: https://www.youtube.com/watch?v=-ynxoEjMaSA

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May 5, 2024

Michael Jordan’s Creative Risktaking

“Talk about the courage. You have Nike contracts. The world is watching you. People admire you, literally the entire planet thinks of you as an icon and you're like, “I’m going to go play baseball”. It blows my mind.” — Jimmy Soni on on taking creative risks… Full episode: https://www.youtube.com/watch?v=-ynxoEjMaSA

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May 4, 2024

Maintaining Direct Relationships with Audiences

“In the same way that Dwayne The Rock Johnson and Taylor Swift cultivated a direct relationship with your audience, you have to cultivate a direct relationship with your audience” — Jimmy Soni on maintaining direct links with your audience… Full episode: https://www.youtube.com/watch?v=-ynxoEjMaSA

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May 2, 2024

Jimmy Soni — The Courage of Creative Risk | Episode 214

Author and friend-of-the-show Jimmy Soni returns to discuss the future of publishing, the changing world of book marketing, the courage of creative risk, and MUCH more! Important Links: - Jimmy’s website - https://jimmysoni.com - Jimmy’s Twitter - https://twitter.com/jimmyasoni - The Great Reshuffle - https://www.youtube.com/playlist?list=PLHoZjyz2rEpl2qvR6Yw2CFn-RFTBXLW9J Show Notes: 0:00:00 Intro 0:00:48 Main…

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April 30, 2024

The Pessimism of Ultimacy

"I think every utopia is a dystopia..." Here's Arjun Khemani on the pessimism of ultimacy… Full episode: https://www.youtube.com/watch?v=Ew4hEtKsgnY

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April 29, 2024

Follow Your Interests

"I think people make more progress if they just follow their interests..." ~ Arjun Khemani explains why he thinks altruism is inefficient… Full episode: https://www.youtube.com/watch?v=Ew4hEtKsgnY

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April 28, 2024

Friendly Aliens

If aliens visited Earth, would they want to steal our resources? "[T]hat's just the most absurd idea somebody could have. I think resources are just limited to the amount of knowledge that people have, and knowledge is what creates resources." ~ Arjun Khemani Full episode: https://www.youtube.com/watch?v=Ew4hEtKsgnY

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April 27, 2024

A Life Without Sacrifice

"I want to live a life without sacrifices and without compromises [...] Sure, you have to make trade-offs, but you choose the better option. And I wouldn't call choosing a better option a sacrifice." ~ Arjun Khemani Full episode: https://www.youtube.com/watch?v=Ew4hEtKsgnY

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April 25, 2024

Arjun Khemani — The Hunt for Better Problems | Episode 213

Arjun Khemani is a 17-year-old writer and podcaster who dropped out of high school to help lead support at Airchat, the social network co-founded by Naval Ravikant. As the host of the Arjun Khemani podcast, Arjun has spoken to a wide range of guests including David Deutsch, David Perell and…

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April 23, 2024

Being a private investigator

"I just find it's a thrilling mental exercise because you're going against the masses and everyone's telling you you're wrong and you are planting a flag and saying, "No, I'm right and I'm going to put my money behind it, or the money of our investors.” -- EddyElfenbein Catch the…

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April 22, 2024

Bypassing the gatekeeprs

"I think the larger theme is that the gatekeepers no longer play the role that they used to be..." -- Eddy Elfenbein Catch the full episode here: https://www.youtube.com/watch?v=HrPdi2PFnk0

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April 22, 2024

The stocks don't know you own them

"The stocks don't know you own them" -- Eddy Elfenbein Catch the full episode here: https://www.youtube.com/watch?v=HrPdi2PFnk0

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April 22, 2024

Second guessing

"...That's one of the problems about quantitative things is you're trying to add numbers, you're trying to distill something that is at root is just highly emotional, and it's a very human entity." -- Eddy Elfenbein Catch the full episode here: https://www.youtube.com/watch?v=HrPdi2PFnk0

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April 19, 2024

The Future of Work | The Great Reshuffle Ep.3

The Great Reshuffle touches every element of our lives, from where we live to how we work, play and communicate. Faced with such seismic change, legacy institutions are choosing to stick their head in the sand. Even as the old models collapse, the knee-jerk deference to the default way of…

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April 18, 2024

Eddy Elfenbein — On Crossing Wall Street | Episode 212

Eddy Elfenbein is an OG finance blogger, ETF manager, and FinTwit legend, with over 25 years of experience working in and around Wall Street. Eddy joins the show to discuss the story behind his longtime blog - Crossing Wall Street - https://www.crossingwallstreet.com/ (CWS), the origins of his famous Buy List,…

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April 15, 2024

The outside world is more interesting than you are

Anna Gat on why "making life beautiful for other people is more important than making it beautiful for yourself" Catch the full episode here: https://www.youtube.com/watch?v=ErrSpO2-o6Q

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April 15, 2024

Silence the inner quarrel

"…unless you're a psychopath, you are not necessarily driven by hubris. You are driven by the weird and strange realization that anybody could do it." -- Anna Gat Catch the full episode here: https://www.youtube.com/watch?v=ErrSpO2-o6Q

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April 15, 2024

Skill leads to moral excellence

Anna Gat on the falsification of "startup fridge-magnets" Catch the full episode here: https://www.youtube.com/watch?v=ErrSpO2-o6Q&t=0s

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April 15, 2024

Intellectual Orphans

“...our generation is characterized by intellectual orphans, people with no tribes whatsoever, even if on paper on their CVs, you would think, 'oh, this person belongs here or there,' if you zoom in, you realize that's very complicated..." - Anna Gat Catch the full episode here: https://www.youtube.com/watch?v=ErrSpO2-o6Q

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April 10, 2024

Anna Gát — We Digress | Episode 211

Friend-of-the-show Anna Gát returns to discuss… well… pretty much everything! ___________________________________________________________________________ On April 13th, O’Shaughnessy Ventures and Interintellect - are co-hosting a Future of Publishing event at the beautiful Pratt Mansion in NYC. O’Shaughnessy Ventures - https://www.osv.llc/ Interintellect - https://interintellect.com/ We’re bringing together established publishers, online writers, new publishing houses,…

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